Cardiovascular Implications of COVID-19 and the QT Prolongation Associated with Pharmacotherapy
1 Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania
2 Department of Cardiology, Pius Brinzeu Clinical Emergency County Hospital Timisoara, 300736 Timisoara, Romania
* Author to whom correspondence should be addressed.
Received: 24 Jun 2025 / Published: 7 Mar 2025
Abstract
The coronavirus pandemic has significantly impacted a substantial part of the global population, and the cardiovascular repercussions of COVID-19 infection have been unveiled for the first time. While the arrhythmogenic effects of the severe inflammatory syndrome associated with the infection are well-established, another critical cause of arrhythmias, particularly ventricular arrhythmias such as ventricular tachycardia, torsades de pointes, or ventricular fibrillation, which can result in cardiac arrest, is the pharmacological treatment employed to manage the disease in hospitalized patients. Among all arrhythmogenic mechanisms, the QT interval prolongation is the most alarming. This review aims to provide a more in-depth exploration of these effects and the potential mechanisms underlying their occurrence.
Keywords: COVID-19; pharmacotherapy; QT prolongation; arrhythmias
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CITE
Ali, L.H.; Dăniluc, L.; Suhov, L.; Pecingina, R.; Viviana Ivan, M. Cardiovascular Implications of COVID-19 and the QT Prolongation Associated with Pharmacotherapy. jept 2025, 1, 4.
Ali LH, Dăniluc L, Suhov L, Pecingina R, Viviana Ivan M. Cardiovascular Implications of COVID-19 and the QT Prolongation Associated with Pharmacotherapy. Journal of Experimental Pharmacology and Toxicology. 2025; 1(1):4.
Ali, Lina Haj; Dăniluc, Larissa; Suhov, Loredana; Pecingina, Radu; Viviana Ivan, Mihaela. 2025. "Cardiovascular Implications of COVID-19 and the QT Prolongation Associated with Pharmacotherapy." jept 1, no. 1: 4.
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