Inclusion complexes of Fluconazole with methylated-betacyclodextrin: influence on physicochemical properties of theguest molecule
1 Deparment of Pharmaceutical Chemistry, ”Victor Babeș” University of Medicine and Pharmacy, Timisoara,
Romania
2 Department of Toxicology, Drug industry, Management and legislation,”Victor Babeș” University of Medicine
and Pharmacy Timisoara, Romania
3 Department of Applied Chemistry and Engineering of Inorganic Compounds and the Environment, Politehnica
University, Timisoara, Romania
* Author to whom correspondence should be addressed.
Received: 26 Jun 2025 / Published: 17 Mar 2025
Abstract
The increase in the incidence of fungal infections and fungal resistance has prompted the research for better therapeutic strategies such as the optimization and improvement of existing antifungal drugs. Fluconazole, one of the most used and well-tolerated antifungal drugs has a series of drawbacks hampering the obtention of an optimal therapeutic response. Complexation with cyclodextrins represents a very-well known approach for improvement of pharmaceutical profile of drugs. The present study aims to obtain and to evaluate the solid inclusion complexes of fluconazole with methylated beta-cyclodextrin, as preliminary experiments in formulation of improved pharmaceutical product of fluconazole. The differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray powder diffractometry were used to characterize the binary systems between fluconazole and methylated-beta-cyclodextrin. The encapsulation of fluconazole into methylated-betacyclodextrin cavity resulted in modifications of the physicochemical properties of the antifungal agent. The formation of the fluconazole-cyclodextrin inclusion complex was confirmed by thermal and spectral methods. Based on the experimental data, a real interaction in solid state between the antifungal agent and cyclodextrin was proved, leading us to propose the kneading product in 1:1 molar ratio for future development of improved pharmaceutical formulation containing fluconazole.
Keywords: fluconazole; methylated beta-cyclodextrin; inclusion complex; thermal analysis; spectroscopic
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CITE
Pârvănescu, R.; Alexa, I.-O.; Dehelean, C.; Colibășanu, D.; Racoviceanu, R.; Lazău, R.; Barbu, S.; Trandafirescu, C. Inclusion complexes of Fluconazole with methylated-betacyclodextrin: influence on physicochemical properties of theguest molecule. jept 2025, 1, 2.
Pârvănescu R, Alexa I-O, Dehelean C, Colibășanu D, Racoviceanu R, Lazău R, Barbu S, Trandafirescu C. Inclusion complexes of Fluconazole with methylated-betacyclodextrin: influence on physicochemical properties of theguest molecule. Journal of Experimental Pharmacology and Toxicology. 2025; 1(1):2.
Pârvănescu, Ramona; Alexa, Ionica-Oana; Dehelean, Cristina; Colibășanu, Daiana; Racoviceanu, Roxana; Lazău, Radu; Barbu, Sanela; Trandafirescu, Cristina. 2025. "Inclusion complexes of Fluconazole with methylated-betacyclodextrin: influence on physicochemical properties of theguest molecule." jept 1, no. 1: 2.
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