TY  - EJOU
AU  - Căpraru, C. Anca-Maria
AU  - Ardelean, A. Simona
AU  - Zurbău-Anghel, Z. Nicoleta
AU  - Dărăban, D. Adriana Maria
AU  - Munteanu, M. Melania
AU  - Rusu, R. Andreea Ioana
TI  - Vitamin D as a Preventive and Therapeutic Agent in Cervical Cancer: Insights from Clinical Studies
T2  - Journal of Experimental Pharmacology and Toxicology

PY  - 2025
VL  - 2
IS  - 2
SN  - 3091-0595

AB  - Cervical cancer remains a significant global health issue, closely linked to persistent human papillomavirus (HPV) infections. Vitamin D, recognized primarily for its role in calcium homeostasis and bone metabolism, has emerged as a promising preventive and therapeutic agent in cancer management. Recent clinical studies have suggested that vitamin D may effectively prevent cervical cancer and aid in the regression of early cervical dysplasia (CIN 1 orc LSIL). However, its therapeutic impact appears limited for advanced cervical dysplasia (CIN 2/3, HSIL) and established cervical cancer cases. Due to the progressive nature of cervical lesions, vitamin D supplementation represents a potentially valuable strategy for secondary prevention. This review critically evaluates current clinical evidence, underscores key insights into vitamin D’s role in cervical cancer management, and highlights existing gaps requiring further research.
KW  - Vitamin D
KW  - calcitriol
KW  - cervical cancer
KW  - human papillomavirus (HPV)
KW  - cervical dysplasia
KW  - CIN (cervical intraepithelial neoplasia)
KW  - LSIL (low-grade squamous intraepithelial lesion)
KW  - HSIL (high-grade squamous intraepithelial lesion)
KW  - cancer prevention
KW  - supplementation
DO  - 10.6425/022025jept006