Implications of periodontitis in cardiovascular diseases: Review
1 Department of Management and Communication in Dental Medicine, Department I, Faculty of Dental
Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, Romania
2 Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania
3 Department of Management and Communication in Dental Medicine, Department I, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, Romania
4 Department of ENT, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara,
Romania
5 Doctoral School of Pharmacy, Victor Babes University of Medicine and Pharmacy of Timisoara, Romania
6 Doctoral School of Dental Medicine, University of Medicine and Pharmacy, 9 Revolutiei 1989 Bv., 300041, Timisoara, Romania
* Author to whom correspondence should be addressed.
Received: 26 Jun 2025 / Published: 10 Mar 2025
Abstract
Periodontal disease is a common condition that affects a large part of the population. Periodontitis occurs when bacteria spread deeper into the tissue and the surroundings structures leading to a chronic, destructive, irreversible inflammatory disease. Oral Gram-positive and Gram-negative bacteria have been frequently identified in blood flow and may play a role in vascular disease. The objective of the study is to examine the relationship between microbial presence in dental plaque and periodontitis, focusing on how these microorganisms may enter the bloodstream, particularly in individuals with cardiovascular diseases. Patients with severe periodontal disease showed endothelial dysfunction and signs of systemic inflammation, placing them at an increased risk level for the development of cardiovascular diseases. Dental diseases including gingivitis, periodontitis, and other odontogenic infections have a higher bacteremia regarding valvular diseases after tooth extraction. Oral bacteria can cause short-term bacteremia during dental treatment especially when is involved periodontitis. Usually, the bacteria enter the circulation and reach body organs through blood, becoming a risk factor for cardiovascular diseases.
Keywords: periodontitis; atherosclerosis; oral microbiome; valvular heart disease;
prevention; gingivitis
OPEN ACCESS
This is an open access article distributed under the Creative Commons Attribution
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provided the original work is properly cited. (CC BY 4.0).
CITE
Sarbu, D.; Kiș, A.M.; Boroghina, A.R.; Negru, M.C.; Joma, M.; Salehi Matin, A.; Popovici, R.A. Implications of periodontitis in cardiovascular diseases: Review. jept 2025, 1, 3.
Sarbu D, Kiș AM, Boroghina AR, Negru MC, Joma M, Salehi Matin A, Popovici RA. Implications of periodontitis in cardiovascular diseases: Review. Journal of Experimental Pharmacology and Toxicology. 2025; 1(1):3.
Sarbu, Diana; Kiș, Andreea Mihaela; Boroghina, Adela Ramona; Negru, Mihaela Cristina; Joma, Mohamad; Salehi Matin, Asad; Popovici, Ramona Amina. 2025. "Implications of periodontitis in cardiovascular diseases: Review." jept 1, no. 1: 3.
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