Hydroxyapatite in Contemporary Dentistry: Functional Versatility, Formulation Advances, and Clinical Relevance
1 Department of Pedodontics, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 9 No., Revolutiei 1989 Bv., 300041 Timisoara, Romania;
2 Pediatric Dentistry Research Center, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 9 No., Revolutiei 1989 Bv., 300041 Timisoara, Romania
3 Doctoral School, Victor Babeş University of Medicine and Pharmacy, 300041 Timişoara, Romania;
4 Department of Surgery I, Victor Babeş University of Medicine and Pharmacy, 300041 Timişoara, Romania
5 Orthodontic Research Center (ORTHO-CENTER), “Victor Babeș” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania;
6 Faculty of Dental Medicine, “Victor Babeș” University of Medicine and Pharmacy from Timișoara, 9 Revoluției 1989 Ave., 300070 Timișoara, Romania
7 Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timișoara, Romania;
8 Research Centre for Pharmacotoxicologic Evaluations (FARMTOX), “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041 Timișoara, Romania
9 Discipline of Oral and Maxillo-Facial Surgery, Faculty of Dental Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Revolutiei Boulevard 9, 300041 Timisoara, Romania;
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* Author to whom correspondence should be addressed.
Received: 2 Jul 2025 / Accepted: 11 Sep 2025 / Published: 29 Sep 2025
Abstract
1. Background/Objectives: Calcium phosphate biomaterials (CPBs), including hydroxyapatite (HA), are among the most commonly used biomaterials in dentistry due to their biocompatibility and similarity to the body’s hard tissues. This review aims to highlight the clinical applications of CPBs in dentistry, focusing mainly on hydroxyapatite and its modern formulations. 2. Methods: A literature search was conducted by analyzing data published up to May 2025 in databases such as PubMed, Web of Science, and Google Scholar using keyword combinations such as “Biomaterials”, “dentistry”, “calcium phosphate”, and “hydroxyapatite”. 3. Results: The findings of this work reveal the wide clinical use of HA, including tooth remineralization, implant coating, bone grafting, and the treatment of dental hypersensitivity. Furthermore, the novel formulations of hydroxyapatite have substantially improved its therapeutic and physicochemical characteristics. 4. Conclusions: The clinical relevance of HA and its modern formulations emphasizes the need for continuous research that will contribute to further enhancement of HA’s therapeutic outcomes.
Keywords: biomaterials; dentistry; calcium phosphate; hydroxyapatite
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This is an open access article distributed under the Creative Commons Attribution
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CITE
Dinu, Ș.; Moldoveanu, A.; Szuhanek, C.; Milutinovici, R.; Ali, D.H.; Talpoș, Ș. Hydroxyapatite in Contemporary Dentistry: Functional Versatility, Formulation Advances, and Clinical Relevance. jept 2025, 2, 5.
Dinu Ș, Moldoveanu A, Szuhanek C, Milutinovici R, Ali DH, Talpoș Ș. Hydroxyapatite in Contemporary Dentistry: Functional Versatility, Formulation Advances, and Clinical Relevance. Journal of Experimental Pharmacology and Toxicology. 2025; 2(2):5.
Dinu, Ștefania; Moldoveanu, Adrian; Szuhanek, Camelia; Milutinovici, Raluca; Ali, Diana Haj; Talpoș, Șerban. 2025. "Hydroxyapatite in Contemporary Dentistry: Functional Versatility, Formulation Advances, and Clinical Relevance." jept 2, no. 2: 5.
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