Vitamin D as a Preventive and Therapeutic Agent in Cervical Cancer: Insights from Clinical Studies
1 Faculty of Pharmacy, “Vasile Goldis” Western University of Arad, Liviu Rebreanu Str., No. 86, Arad, Romania
2 Poiana Mare Psychiatry Hospital, Gării Str., No. 40, Poiana Mare, Romania
3 Faculty of Medicine, “Vasile Goldis” Western University of Arad, Liviu Rebreanu Str., No. 86, Arad, Romania
4 email:
* Author to whom correspondence should be addressed.
Received: 1 Jul 2025 / Accepted: 11 Sep 2025 / Published: 29 Sep 2025
Abstract
Cervical cancer remains a significant global health issue, closely linked to persistent human papillomavirus (HPV) infections. Vitamin D, recognized primarily for its role in calcium homeostasis and bone metabolism, has emerged as a promising preventive and therapeutic agent in cancer management. Recent clinical studies have suggested that vitamin D may effectively prevent cervical cancer and aid in the regression of early cervical dysplasia (CIN 1 orc LSIL). However, its therapeutic impact appears limited for advanced cervical dysplasia (CIN 2/3, HSIL) and established cervical cancer cases. Due to the progressive nature of cervical lesions, vitamin D supplementation represents a potentially valuable strategy for secondary prevention. This review critically evaluates current clinical evidence, underscores key insights into vitamin D’s role in cervical cancer management, and highlights existing gaps requiring further research.
Keywords: Vitamin D; calcitriol; cervical cancer; human papillomavirus (HPV); cervical dysplasia; CIN (cervical intraepithelial neoplasia); LSIL (low-grade squamous intraepithelial lesion); HSIL (high-grade squamous intraepithelial lesion); cancer prevention; supplementation
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This is an open access article distributed under the Creative Commons Attribution
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CITE
Căpraru, A.-M.; Ardelean, S.; Zurbău-Anghel, N.; Dărăban, A.M.; Munteanu, M.; Rusu, A.I. Vitamin D as a Preventive and Therapeutic Agent in Cervical Cancer: Insights from Clinical Studies. jept 2025, 2, 6.
Căpraru A-M, Ardelean S, Zurbău-Anghel N, Dărăban AM, Munteanu M, Rusu AI. Vitamin D as a Preventive and Therapeutic Agent in Cervical Cancer: Insights from Clinical Studies. Journal of Experimental Pharmacology and Toxicology. 2025; 2(2):6.
Căpraru, Anca-Maria; Ardelean, Simona; Zurbău-Anghel, Nicoleta; Dărăban, Adriana Maria; Munteanu, Melania; Rusu, Andreea Ioana. 2025. "Vitamin D as a Preventive and Therapeutic Agent in Cervical Cancer: Insights from Clinical Studies." jept 2, no. 2: 6.
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